Metabolic Therapeutics:

the science behind exploiting weaknesses in cancer metabolism.

In the third episode of the Beating Brain Cancer podcast we had the great pleasure of interviewing Dr. Angela Poff, Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida.

Dr. Poff works in the Laboratory of Nutritional and Metabolic Medicine under the mentorship of Dr. Dominic D'Agostino. Her research focuses on the development and testing of non-toxic metabolic therapies for cancer and neurological disorders.

Dr. Poff's research focuses primarily on vivo research using rodent models with metastatic cancer derived from human glioblastoma cell lines.

Dr. Angela Poff

The aim of her work is to observe the effects of nutritional ketosis, exogenous ketones and hyperbaric oxygen therapy and outline the underlying synergistic anti-cancer mechanisms behind these treatments.   

The audio recording of this interview is available here: 

Metabolic Therapeutics- Dr. Angela Poff

Interview highlights:

Metabolic therapy (general)

What is metabolic therapy? - 03:25

The role glucose and insulin in cancer proliferation- 05:30

The ketogenic diet

The ketogenic diet and cancer- 5:45

Sleep quality on the ketogenic diet- 17:18

Nutritional ketosis, calorie restriction and fasting- 18:19

The rodent model

The mouse model and findings- 07:45

Types of ketogenic diet applied in mouse models- 08:25

Confounding factors to using rodent models- 15:34

DHA and the omega 3 and 6 ratio

DHA (docosahexaenoic acid) and the omega 3 and 6 ratio of the ketogenic diet- 10:49

DHA has potent anti-cancer effects- 13:05

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy (HBOT). What is it and why is it useful?- 22:03

Concerns about HBOT driving cancer growth- 27:37

Avoiding antioxidants during HBOT?- 30:45

Exogenous ketones

What are exogenous ketones and what are their applications?- 35:01

How do ketone esters differ from commercially available exogenous ketones?- 39:31

Epilepsy, anti-epileptic drugs and combination therapies

Anti seizure effects of acetoacetate and acetate- 40:20

Potential application of the intravenous ketogenic diet- 42:20

Are rodents monitored for seizures and could this alter study results?- 44:10

Anti-epileptic drugs, combination therapies and the ketogenic diet- 47:17